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~ Down Syndrome ~  __**History**__ __How do you get this disease?__ ** **__ Chromosome affected __**    __**
 * **Discovered by Jerome Lejeune, in 1959 ** 
 * **<span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">He proved that Down Syndrome was a genetic disease **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">In 1866, ****<span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">John Langdon Down was the first to pubish a description of this disease **
 * <span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);"><span style="font-size: 180%; text-align: left; display: block; font-family: 'Lucida Console',Monaco,monospace; color: rgb(240, 45, 120);"> <span style="font-size: 130%; color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace;">
 * **<span style="font-size: 130%; color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace;">Its caused by extra genetic material **
 * **<span style="font-size: 130%; color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace;">In this disease, 95% of all cases are caused by either the sperm or the egg cell having two 21st chromosomes instead of one **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="font-size: 130%; color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace;">The gene is usually passed on by its mother, its recessive **<span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">
 * **<span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">There is an extra 21st chromosome which is microscopic **<span style="background-color: rgb(255, 255, 255); font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">

Affecting males & females **__<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;"> <span style="background-color: rgb(255, 255, 255);"><span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);"> <span style="background-color: rgb(255, 255, 255);"><span style="font-size: 170%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);"> __**Early & later symptoms**__ <span style="background-color: rgb(255, 255, 255);"><span style="color: rgb(252, 54, 159); font-size: 170%; font-family: 'Lucida Console',Monaco,monospace;"> __**Body parts affected**__ <span style="background-color: rgb(255, 255, 255);"><span style="color: rgb(252, 54, 159);">__<span style="font-family: 'Lucida Console',Monaco,monospace; font-size: 170%; color: rgb(252, 54, 159);"> <span style="background-color: rgb(255, 255, 255);"><span style="font-family: 'Lucida Console',Monaco,monospace; font-size: 170%; color: rgb(252, 54, 159);"> __**Related to other diseases or conditions?**__ <span style="background-color: rgb(255, 255, 255); color: rgb(252, 54, 159);">
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">This disease affects males ans females equally **<span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">Early: eyes slant upwards, small ear, flat back heads, short fingers, and low birth weight. **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">No later symptoms **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 130%;">Hypotonia and hyper re-flexibility of the joints **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 130%;">Small nasal bridge **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 130%;">Small, over-folding of the ears **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 130%;">Short neck **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 130%;">Fine, short hair **
 * <span style="color: rgb(252, 54, 159);">Treatments ** __
 * <span style="background-color: rgb(255, 255, 255);">**<span style="font-size: 120%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">NONE! **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">Can cause: heart defects, leukemia, dementia, and infectious diseases **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">Also other problem such as gastrointestinal blockage, thyroid problems, hearing loss, and poor vision **

<span style="font-family: 'Lucida Console',Monaco,monospace; font-size: 160%;">__**Current research being performed on Down Syndrome**__ <span style="background-color: rgb(255, 255, 255);"><span style="font-family: 'Lucida Console',Monaco,monospace; font-size: 120%; color: rgb(252, 54, 159);">**<span style="font-family: 'Lucida Console',Monaco,monospace; font-size: 150%; color: rgb(252, 54, 159);"> __FACTS:__ ** <span style="background-color: rgb(255, 255, 255);"><span style="font-size: 170%; color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace;"> __**Works Cited**__ <span style="font-size: 130%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">The nation institutes of health has developed a research plan to advance understanding of the disease, and speed development of new treatments for the condition **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="color: rgb(252, 54, 159); font-family: 'Lucida Console',Monaco,monospace; font-size: 120%;">The plans set research goals for the next 10 years that build upon earlier research advances fostered by the NIH **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="font-size: 120%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">Occurs in 1 out of every 800 births in the u.s. **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="font-size: 120%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">Also called Trisomy 21 **
 * <span style="background-color: rgb(255, 255, 255);">**<span style="font-size: 156%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);"> <span style="font-size: 120%; font-family: 'Lucida Console',Monaco,monospace; color: rgb(252, 54, 159);">There are more than 400,000 people living with Down Syndrome in the u.s. **
 * <span style="background-color: rgb(255, 255, 255);">[]
 * <span style="background-color: rgb(255, 255, 255);"> · [|http://www.downs-syndrome.org.uk/component/content/article/35-general/160-4-when-was-downs-syndrome-discovered.htm]
 * <span style="background-color: rgb(255, 255, 255);"> · []
 * <span style="background-color: rgb(255, 255, 255);"> · [|www.nhs.uk/Conditions/**Downs**-**syndrome**]
 * <span style="background-color: rgb(255, 255, 255);"> · []
 * <span style="background-color: rgb(255, 255, 255);"> · []
 * <span style="background-color: rgb(255, 255, 255);"> · []
 * <span style="background-color: rgb(255, 255, 255); font-family: Symbol;">· [|www.ndss.org/index.php?option=com_content&view=article&id=54:down-syndrome-fact-sheet&catid=35:about-down-syndrome&Itemid=74]